APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes(1–5). Here we examine the mechanism underlying chromothripsis and kata...

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Detalles Bibliográficos
Autores principales: Maciejowski, John, Chatzipli, Aikaterini, Dananberg, Alexandra, Chu, Kevan, Toufektchan, Eleonore, Klimczak, Leszek J., Gordenin, Dmitry A., Campbell, Peter J., de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484228/
https://www.ncbi.nlm.nih.gov/pubmed/32719516
http://dx.doi.org/10.1038/s41588-020-0667-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484228/
https://www.ncbi.nlm.nih.gov/pubmed/32719516
http://dx.doi.org/10.1038/s41588-020-0667-5

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