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APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis
Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes(1–5). Here we examine the mechanism underlying chromothripsis and kata...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484228/ https://www.ncbi.nlm.nih.gov/pubmed/32719516 http://dx.doi.org/10.1038/s41588-020-0667-5 |