Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia—Schizophrenia Increases Developmental Vulnerability to TNFα

Schizophrenia (SZ) is a neurodevelopmental genetic disorder in which maternal immune activation (MIA) and increased tumor necrosis factor-α (TNF-α) may contribute. Previous studies using iPSC-derived cerebral organoids and neuronal cells demonstrated developmental malformation and transcriptional dy...

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Detalles Bibliográficos
Autores principales: Benson, Courtney A., Powell, Hana R., Liput, Michal, Dinham, Siddhartha, Freedman, David A., Ignatowski, Tracey A., Stachowiak, Ewa K., Stachowiak, Michal K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484483/
https://www.ncbi.nlm.nih.gov/pubmed/33005129
http://dx.doi.org/10.3389/fncel.2020.00233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484483/
https://www.ncbi.nlm.nih.gov/pubmed/33005129
http://dx.doi.org/10.3389/fncel.2020.00233

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