CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

The BH3-only protein NOXA is a regulator of mitochondrial apoptosis by specifically antagonizing the anti-apoptotic protein MCL-1. Here we show that the E3 ubiquitin ligase CHIP controls NOXA stability after DNA damage. Our findings reveal that CHIP and MCL-1 are binding partners of NOXA and differe...

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Detalles Bibliográficos
Autores principales: Albert, Marie-Christine, Brinkmann, Kerstin, Pokrzywa, Wojciech, Günther, Saskia Diana, Krönke, Martin, Hoppe, Thorsten, Kashkar, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484759/
https://www.ncbi.nlm.nih.gov/pubmed/32913203
http://dx.doi.org/10.1038/s41419-020-02923-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484759/
https://www.ncbi.nlm.nih.gov/pubmed/32913203
http://dx.doi.org/10.1038/s41419-020-02923-x

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