QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates: formulation, characterization and pharmacokinetic evaluation using HPLC-Fluorescence detection method

This study is based on the QbD development of extended-release (ER) extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic evaluation with immediate-release (IR) pellets. HPLC-fluorescence method was developed and validated for plasma drug analysis. IR drug cores were prep...

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Detalles Bibliográficos
Autores principales: Qazi, Faaiza, Shoaib, Muhammad Harris, Yousuf, Rabia Ismail, Siddiqui, Fahad, Nasiri, Muhammad Iqbal, Ahmed, Kamran, Muhammad, Iyad Naeem, Ahmed, Farrukh Rafiq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484796/
https://www.ncbi.nlm.nih.gov/pubmed/32913337
http://dx.doi.org/10.1038/s41598-020-71751-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484796/
https://www.ncbi.nlm.nih.gov/pubmed/32913337
http://dx.doi.org/10.1038/s41598-020-71751-y

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