Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA

Endometrial cancer stem cells (ECSCs) are stem-like cells endowed with self-renewal and differentiation abilities, and these cells are essential for cancer progression in endometrial cancer (EC). As hallmarks of the tumour microenvironment (TME), hypoxia and hypoxia-inducing factors (HIFs) give rise...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Guofang, Liu, Binya, Yin, Shasha, Li, Shuangdi, Guo, Yu’e, Wang, Mengfei, Wang, Kai, Wan, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484801/
https://www.ncbi.nlm.nih.gov/pubmed/32913192
http://dx.doi.org/10.1038/s41389-020-00265-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484801/
https://www.ncbi.nlm.nih.gov/pubmed/32913192
http://dx.doi.org/10.1038/s41389-020-00265-z

Ejemplares similares