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Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA

Endometrial cancer stem cells (ECSCs) are stem-like cells endowed with self-renewal and differentiation abilities, and these cells are essential for cancer progression in endometrial cancer (EC). As hallmarks of the tumour microenvironment (TME), hypoxia and hypoxia-inducing factors (HIFs) give rise...

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Detalles Bibliográficos
Autores principales:	Chen, Guofang, Liu, Binya, Yin, Shasha, Li, Shuangdi, Guo, Yu’e, Wang, Mengfei, Wang, Kai, Wan, Xiaoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484801/ https://www.ncbi.nlm.nih.gov/pubmed/32913192 http://dx.doi.org/10.1038/s41389-020-00265-z

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