Astrin: A Key Player in Mitosis and Cancer
Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484939/ https://www.ncbi.nlm.nih.gov/pubmed/32984344 http://dx.doi.org/10.3389/fcell.2020.00866 |
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author | Ying, Zhenguang Yang, Jing Li, Wei Wang, Xia Zhu, Zeyao Jiang, Weipeng Li, Chunman Sha, Ou |
author_facet | Ying, Zhenguang Yang, Jing Li, Wei Wang, Xia Zhu, Zeyao Jiang, Weipeng Li, Chunman Sha, Ou |
author_sort | Ying, Zhenguang |
collection | PubMed |
description | Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor. |
format | Online Article Text |
id | pubmed-7484939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74849392020-09-24 Astrin: A Key Player in Mitosis and Cancer Ying, Zhenguang Yang, Jing Li, Wei Wang, Xia Zhu, Zeyao Jiang, Weipeng Li, Chunman Sha, Ou Front Cell Dev Biol Cell and Developmental Biology Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor. Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7484939/ /pubmed/32984344 http://dx.doi.org/10.3389/fcell.2020.00866 Text en Copyright © 2020 Ying, Yang, Li, Wang, Zhu, Jiang, Li and Sha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Ying, Zhenguang Yang, Jing Li, Wei Wang, Xia Zhu, Zeyao Jiang, Weipeng Li, Chunman Sha, Ou Astrin: A Key Player in Mitosis and Cancer |
title | Astrin: A Key Player in Mitosis and Cancer |
title_full | Astrin: A Key Player in Mitosis and Cancer |
title_fullStr | Astrin: A Key Player in Mitosis and Cancer |
title_full_unstemmed | Astrin: A Key Player in Mitosis and Cancer |
title_short | Astrin: A Key Player in Mitosis and Cancer |
title_sort | astrin: a key player in mitosis and cancer |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484939/ https://www.ncbi.nlm.nih.gov/pubmed/32984344 http://dx.doi.org/10.3389/fcell.2020.00866 |
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