Astrin: A Key Player in Mitosis and Cancer

Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ying, Zhenguang, Yang, Jing, Li, Wei, Wang, Xia, Zhu, Zeyao, Jiang, Weipeng, Li, Chunman, Sha, Ou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484939/
https://www.ncbi.nlm.nih.gov/pubmed/32984344
http://dx.doi.org/10.3389/fcell.2020.00866
_version_ 1783581075067371520
author Ying, Zhenguang
Yang, Jing
Li, Wei
Wang, Xia
Zhu, Zeyao
Jiang, Weipeng
Li, Chunman
Sha, Ou
author_facet Ying, Zhenguang
Yang, Jing
Li, Wei
Wang, Xia
Zhu, Zeyao
Jiang, Weipeng
Li, Chunman
Sha, Ou
author_sort Ying, Zhenguang
collection PubMed
description Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor.
format Online
Article
Text
id pubmed-7484939
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-74849392020-09-24 Astrin: A Key Player in Mitosis and Cancer Ying, Zhenguang Yang, Jing Li, Wei Wang, Xia Zhu, Zeyao Jiang, Weipeng Li, Chunman Sha, Ou Front Cell Dev Biol Cell and Developmental Biology Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor. Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7484939/ /pubmed/32984344 http://dx.doi.org/10.3389/fcell.2020.00866 Text en Copyright © 2020 Ying, Yang, Li, Wang, Zhu, Jiang, Li and Sha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ying, Zhenguang
Yang, Jing
Li, Wei
Wang, Xia
Zhu, Zeyao
Jiang, Weipeng
Li, Chunman
Sha, Ou
Astrin: A Key Player in Mitosis and Cancer
title Astrin: A Key Player in Mitosis and Cancer
title_full Astrin: A Key Player in Mitosis and Cancer
title_fullStr Astrin: A Key Player in Mitosis and Cancer
title_full_unstemmed Astrin: A Key Player in Mitosis and Cancer
title_short Astrin: A Key Player in Mitosis and Cancer
title_sort astrin: a key player in mitosis and cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484939/
https://www.ncbi.nlm.nih.gov/pubmed/32984344
http://dx.doi.org/10.3389/fcell.2020.00866
work_keys_str_mv AT yingzhenguang astrinakeyplayerinmitosisandcancer
AT yangjing astrinakeyplayerinmitosisandcancer
AT liwei astrinakeyplayerinmitosisandcancer
AT wangxia astrinakeyplayerinmitosisandcancer
AT zhuzeyao astrinakeyplayerinmitosisandcancer
AT jiangweipeng astrinakeyplayerinmitosisandcancer
AT lichunman astrinakeyplayerinmitosisandcancer
AT shaou astrinakeyplayerinmitosisandcancer