Cargando…

Constant Levels of Tau Phosphorylation in the Brain of htau Mice

Excessive tau phosphorylation is the hallmark of tauopathies. Today’s research thus focusses on the development of drugs targeting this pathological feature. To test new drugs in preclinical studies, animal models are needed that properly mimic this pathological hallmark. The htau mouse is a well-kn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neddens, Joerg, Daurer, Magdalena, Loeffler, Tina, Alzola Aldamizetxebarria, Saioa, Flunkert, Stefanie, Hutter-Paier, Birgit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485327/ https://www.ncbi.nlm.nih.gov/pubmed/32982685 http://dx.doi.org/10.3389/fnmol.2020.00136

Ejemplares similares

Quantification of Huntington’s Disease Related Markers in the R6/2 Mouse Model
por: Etxeberria-Rekalde, Estibaliz, et al.
Publicado: (2021)

Phosphorylation of different tau sites during progression of Alzheimer’s disease
por: Neddens, Joerg, et al.
Publicado: (2018)

Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer’s disease and related murine models
por: Neddens, Joerg, et al.
Publicado: (2020)

Hepatic and neuronal phenotype of NPC1(−/−) mice
por: Santiago-Mujica, Estibaliz, et al.
Publicado: (2019)

Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value
por: Loeffler, Tina, et al.
Publicado: (2020)

Transgene integration causes RARB downregulation in homozygous Tg4–42 mice
por: Hinteregger, Barbara, et al.
Publicado: (2020)

Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease
por: Hinteregger, Barbara, et al.
Publicado: (2021)

Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
por: Molnar-Kasza, Agnes, et al.
Publicado: (2021)

Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models
por: Sharghi, Shirin, et al.
Publicado: (2023)

Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease
por: Schiffer, Victoria, et al.
Publicado: (2020)

Decreased Plasma Aβ in Hyperlipidemic APP(SL) Transgenic Mice Is Associated with BBB Dysfunction
por: Löffler, Tina, et al.
Publicado: (2016)

Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling
por: Filip, Thomas, et al.
Publicado: (2021)

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice
por: Zhang, Qing, et al.
Publicado: (2018)

Editorial: Neuronopathic lysosomal storage diseases - specific neuronal characteristics and therapeutic approaches
por: Flunkert, Stefanie, et al.
Publicado: (2022)

mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms
por: Scherz, Barbara, et al.
Publicado: (2018)

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice
por: Bretland, Katie A., et al.
Publicado: (2021)

Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates
por: Löffler, Tina, et al.
Publicado: (2012)

Treatment With Nilvadipine Mitigates Inflammatory Pathology and Improves Spatial Memory in Aged hTau Mice After Repetitive Mild TBI
por: Morin, Alexander, et al.
Publicado: (2018)

Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model
por: Ferrer, Isidro, et al.
Publicado: (2022)

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model
por: Amschl, David, et al.
Publicado: (2013)

Neuroinflammation and related neuropathologies in APP(SL) mice: further value of this in vivo model of Alzheimer’s disease
por: Löffler, Tina, et al.
Publicado: (2014)

In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice
por: Davidowitz, Eliot J., et al.
Publicado: (2020)

Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice
por: Rabl, R., et al.
Publicado: (2017)

Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice
por: Qian, Shuo, et al.
Publicado: (2018)

Non-Selective Calcium Channel Blocker Bepridil Decreases Secondary Pathology in Mice after Photothrombotic Cortical Lesion
por: Lipsanen, Anu, et al.
Publicado: (2013)

Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study
por: Ferguson, Scott A., et al.
Publicado: (2017)

P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities
por: Xie, Jia‐Zhao, et al.
Publicado: (2022)

A Comprehensive Introduction to Magnetic Resonance Imaging Relaxometry and Contrast Agents
por: Alzola-Aldamizetxebarria, Saioa, et al.
Publicado: (2022)

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
por: Gamache, Julia, et al.
Publicado: (2019)

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology
por: Gratuze, Maud, et al.
Publicado: (2017)

A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology
por: Lippi, Stephen L. P., et al.
Publicado: (2018)

Common and Specific Marks of Different Tau Strains Following Intra-Hippocampal Injection of AD, PiD, and GGT Inoculum in hTau Transgenic Mice
por: Ferrer, Isidro, et al.
Publicado: (2022)

Leukotriene Signaling as a Target in α-Synucleinopathies
por: Strempfl, Katharina, et al.
Publicado: (2022)

Impaired burrowing is the most prominent behavioral deficit of aging htau mice
por: Geiszler, Philippine Camilla, et al.
Publicado: (2016)

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
por: Barron, Matthew R., et al.
Publicado: (2020)

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit
por: Liu, Xinghua, et al.
Publicado: (2017)

Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia
por: Hull, Claire, et al.
Publicado: (2019)

The Evolution of Tau Phosphorylation and Interactions
por: Trushina, Nataliya I., et al.
Publicado: (2019)

Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice
por: Kang, Eun-Bum, et al.
Publicado: (2015)

A 3-month-delayed treatment with anatabine improves chronic outcomes in two different models of repetitive mild traumatic brain injury in hTau mice
por: Morin, Alexander, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ii23f0rhobk9o7idu675qhhmb1