Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis

Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and disease progression. The aim of this study was to determine the effect of oleuropein on Cx43...

Descripción completa

Detalles Bibliográficos
Autores principales: Varela-Eirín, Marta, Carpintero-Fernández, Paula, Sánchez-Temprano, Agustín, Varela-Vázquez, Adrián, Paíno, Carlos Luis, Casado-Díaz, Antonio, Continente, Alfonso Calañas, Mato, Virginia, Fonseca, Eduardo, Kandouz, Mustapha, Blanco, Alfonso, Caeiro, José Ramón, Mayán, María D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485729/
https://www.ncbi.nlm.nih.gov/pubmed/32745074
http://dx.doi.org/10.18632/aging.103801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485729/
https://www.ncbi.nlm.nih.gov/pubmed/32745074
http://dx.doi.org/10.18632/aging.103801

Ejemplares similares