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Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis
Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and disease progression. The aim of this study was to determine the effect of oleuropein on Cx43...
Autores principales: | Varela-Eirín, Marta, Carpintero-Fernández, Paula, Sánchez-Temprano, Agustín, Varela-Vázquez, Adrián, Paíno, Carlos Luis, Casado-Díaz, Antonio, Continente, Alfonso Calañas, Mato, Virginia, Fonseca, Eduardo, Kandouz, Mustapha, Blanco, Alfonso, Caeiro, José Ramón, Mayán, María D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485729/ https://www.ncbi.nlm.nih.gov/pubmed/32745074 http://dx.doi.org/10.18632/aging.103801 |
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