Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes

We aimed to evaluate choroid structural changes using swept-source optical coherence tomography (SS-OCT) following hemodialysis initiation in diabetic and nondiabetic patients with end-stage kidney disease (ESKD). In this multicenter, prospective, cross-sectional study, diabetic (DM group; 30 eyes;...

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Autores principales: Nakano, Hideyuki, Hasebe, Hiruma, Murakami, Kenji, Cho, Hiroyuki, Kondo, Daisuke, Iino, Noriaki, Fukuchi, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485894/
https://www.ncbi.nlm.nih.gov/pubmed/32915894
http://dx.doi.org/10.1371/journal.pone.0239072
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author Nakano, Hideyuki
Hasebe, Hiruma
Murakami, Kenji
Cho, Hiroyuki
Kondo, Daisuke
Iino, Noriaki
Fukuchi, Takeo
author_facet Nakano, Hideyuki
Hasebe, Hiruma
Murakami, Kenji
Cho, Hiroyuki
Kondo, Daisuke
Iino, Noriaki
Fukuchi, Takeo
author_sort Nakano, Hideyuki
collection PubMed
description We aimed to evaluate choroid structural changes using swept-source optical coherence tomography (SS-OCT) following hemodialysis initiation in diabetic and nondiabetic patients with end-stage kidney disease (ESKD). In this multicenter, prospective, cross-sectional study, diabetic (DM group; 30 eyes; 16 patients) and nondiabetic patients (NDM group; 30 eyes; 15 patients) with ESKD were evaluated after hemodialysis initiation. SS-OCT findings were analyzed using a manual delineation technique and binarization method before the first and last hemodialysis sessions, conducted approximately 2 weeks apart. Subfoveal choroidal thickness changes and mean large choroidal vessel layer thickness were significantly greater in the DM group (−13.3% ± 2.5% and −14.5% ± 5.2%, respectively) than the NDM group (−9.5% ± 3.1% and −9.2% ± 3.4%, respectively; p = 0.049 and p = 0.02, respectively). Binarized SS-OCT analysis revealed that the mean subfoveal choroidal area was significantly larger in the DM group (−21.9% ± 6.5%) than the NDM group (−17.2% ± 5.9%; p = 0.032). The change ratio in mean luminal area values was significantly greater in the DM group (−27.7% ± 8.7%) than the NDM group (−17.7% ± 5.8%; p = 0.007). The DM group exhibited substantial changes in the choroidal layer, possibly reflecting choroidal vascular disorders caused by diabetes.
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spelling pubmed-74858942020-09-21 Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes Nakano, Hideyuki Hasebe, Hiruma Murakami, Kenji Cho, Hiroyuki Kondo, Daisuke Iino, Noriaki Fukuchi, Takeo PLoS One Research Article We aimed to evaluate choroid structural changes using swept-source optical coherence tomography (SS-OCT) following hemodialysis initiation in diabetic and nondiabetic patients with end-stage kidney disease (ESKD). In this multicenter, prospective, cross-sectional study, diabetic (DM group; 30 eyes; 16 patients) and nondiabetic patients (NDM group; 30 eyes; 15 patients) with ESKD were evaluated after hemodialysis initiation. SS-OCT findings were analyzed using a manual delineation technique and binarization method before the first and last hemodialysis sessions, conducted approximately 2 weeks apart. Subfoveal choroidal thickness changes and mean large choroidal vessel layer thickness were significantly greater in the DM group (−13.3% ± 2.5% and −14.5% ± 5.2%, respectively) than the NDM group (−9.5% ± 3.1% and −9.2% ± 3.4%, respectively; p = 0.049 and p = 0.02, respectively). Binarized SS-OCT analysis revealed that the mean subfoveal choroidal area was significantly larger in the DM group (−21.9% ± 6.5%) than the NDM group (−17.2% ± 5.9%; p = 0.032). The change ratio in mean luminal area values was significantly greater in the DM group (−27.7% ± 8.7%) than the NDM group (−17.7% ± 5.8%; p = 0.007). The DM group exhibited substantial changes in the choroidal layer, possibly reflecting choroidal vascular disorders caused by diabetes. Public Library of Science 2020-09-11 /pmc/articles/PMC7485894/ /pubmed/32915894 http://dx.doi.org/10.1371/journal.pone.0239072 Text en © 2020 Nakano et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nakano, Hideyuki
Hasebe, Hiruma
Murakami, Kenji
Cho, Hiroyuki
Kondo, Daisuke
Iino, Noriaki
Fukuchi, Takeo
Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes
title Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes
title_full Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes
title_fullStr Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes
title_full_unstemmed Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes
title_short Choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes
title_sort choroid structure analysis following initiation of hemodialysis by using swept-source optical coherence tomography in patients with and without diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485894/
https://www.ncbi.nlm.nih.gov/pubmed/32915894
http://dx.doi.org/10.1371/journal.pone.0239072
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