Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel

In vitro studies have indicated that the P2Y12 receptor antagonist selatogrel is a substrate of organic anion‐transporting‐polypeptide (OATP)1B1 and OATP1B3 that are known to mediate hepatic uptake. Selatogrel is primarily eliminated via the biliary route. Therefore, the study aim was to investigate...

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Detalles Bibliográficos
Autores principales: Schilling, Uta, Dingemanse, Jasper, Voors‐Pette, Christine, Romeijn, Christel, Dogterom, Peter, Ufer, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485944/
https://www.ncbi.nlm.nih.gov/pubmed/32166864
http://dx.doi.org/10.1111/cts.12774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485944/
https://www.ncbi.nlm.nih.gov/pubmed/32166864
http://dx.doi.org/10.1111/cts.12774

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