Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits

Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated with neurodegeneration, spasticity, and motor impairment. Complicated forms (complicated HSP [cHSP]) further include cognitive deficits and deme...

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Detalles Bibliográficos
Autores principales: Lopes, André T., Hausrat, Torben J., Heisler, Frank F., Gromova, Kira V., Lombino, Franco L., Fischer, Timo, Ruschkies, Laura, Breiden, Petra, Thies, Edda, Hermans-Borgmeyer, Irm, Schweizer, Michaela, Schwarz, Jürgen R., Lohr, Christian, Kneussel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485986/
https://www.ncbi.nlm.nih.gov/pubmed/32866173
http://dx.doi.org/10.1371/journal.pbio.3000820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485986/
https://www.ncbi.nlm.nih.gov/pubmed/32866173
http://dx.doi.org/10.1371/journal.pbio.3000820

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