Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents

DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability. These lesions also contribute to the efficacy of radiotherapy and many cancer chemotherapeutics. DNA repair efficiency is regulated by both intracellular and extracellular chemical signals. However, it is la...

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Detalles Bibliográficos
Autores principales: Deng, Min, Lin, Jing, Nowsheen, Somaira, Liu, Tongzheng, Zhao, Yingchun, Villalta, Peter W., Sicard, Delphine, Tschumperlin, Daniel J., Lee, SeungBaek, Kim, JungJin, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486107/
https://www.ncbi.nlm.nih.gov/pubmed/32917705
http://dx.doi.org/10.1126/sciadv.abb2630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486107/
https://www.ncbi.nlm.nih.gov/pubmed/32917705
http://dx.doi.org/10.1126/sciadv.abb2630

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