The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

The glycoprotein uromodulin (UMOD) is the most abundant protein in human urine and forms filamentous homopolymers that encapsulate and aggregate uropathogens, promoting pathogen clearance by urine excretion. Despite its critical role in the innate immune response against urinary tract infections, th...

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Detalles Bibliográficos
Autores principales: Stanisich, Jessica J, Zyla, Dawid S, Afanasyev, Pavel, Xu, Jingwei, Kipp, Anne, Olinger, Eric, Devuyst, Olivier, Pilhofer, Martin, Boehringer, Daniel, Glockshuber, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486124/
https://www.ncbi.nlm.nih.gov/pubmed/32815518
http://dx.doi.org/10.7554/eLife.60265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486124/
https://www.ncbi.nlm.nih.gov/pubmed/32815518
http://dx.doi.org/10.7554/eLife.60265

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