Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Abnormal epigenetic patterns correlate with effector T cell malfunction in tumors(1–4). However, their causal link is unknown. Here, we show that tumor cells disrupt methionine metabolism in CD8(+) T cells, thereby lowering intracellular methionine levels and the methyl donor S-adenosylmethionine (S...

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Detalles Bibliográficos
Autores principales: Bian, Yingjie, Li, Wei, Kremer, Daniel M., Sajjakulnukit, Peter, Li, Shasha, Crespo, Joel, Nwosu, Zeribe C., Zhang, Li, Czerwonka, Arkadiusz, Pawłowska, Anna, Xia, Houjun, Li, Jing, Liao, Peng, Yu, Jiali, Vatan, Linda, Szeliga, Wojciech, Wei, Shuang, Grove, Sara, Liu, J. Rebecca, McLean, Karen, Cieslik, Marcin, Chinnaiyan, Arul M., Zgodziński, Witold, Wallner, Grzegorz, Wertel, Iwona, Okła, Karolina, Kryczek, Ilona, Lyssiotis, Costas A., Zou, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486248/
https://www.ncbi.nlm.nih.gov/pubmed/32879489
http://dx.doi.org/10.1038/s41586-020-2682-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486248/
https://www.ncbi.nlm.nih.gov/pubmed/32879489
http://dx.doi.org/10.1038/s41586-020-2682-1

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