Shared structural mechanisms of general anesthetics and benzodiazepines

Most general anesthetics and classical benzodiazepines act through positive modulation of γ-aminobutyric acid type A (GABA(A)) receptors to dampen neuronal activity in the brain(1–5). Direct structural information for how these drugs work at their physiological receptor sites is absent for general a...

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Detalles Bibliográficos
Autores principales: Kim, Jeong Joo, Gharpure, Anant, Teng, Jinfeng, Zhuang, Yuxuan, Howard, Rebecca J., Zhu, Shaotong, Noviello, Colleen M., Walsh, Richard M., Lindahl, Erik, Hibbs, Ryan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486282/
https://www.ncbi.nlm.nih.gov/pubmed/32879488
http://dx.doi.org/10.1038/s41586-020-2654-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486282/
https://www.ncbi.nlm.nih.gov/pubmed/32879488
http://dx.doi.org/10.1038/s41586-020-2654-5

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