Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death

Mixed lineage kinase domain-like (MLKL) is an essential molecule of necroptosis, a cell death process that is initiated by direct disruption of the plasma membrane. During necroptosis, MLKL is phosphorylated by receptor interacting protein kinase-3 (RIPK3 or RIP3), and then translocates to the plasm...

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Detalles Bibliográficos
Autores principales: Park, Se-Yeon, Park, Han-Hee, Park, Sang-Yeong, Hong, Sun Mi, Yoon, Seongmin, Morgan, Michael J., Kim, You-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486371/
https://www.ncbi.nlm.nih.gov/pubmed/32917855
http://dx.doi.org/10.1038/s41419-020-02941-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486371/
https://www.ncbi.nlm.nih.gov/pubmed/32917855
http://dx.doi.org/10.1038/s41419-020-02941-9

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