Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation

Endosome maturation depends on membrane contact sites (MCSs) formed between endoplasmic reticulum (ER) and endolysosomes (LyLEs). The mechanism underlying lipid supply for this process and its pathophysiological relevance remains unclear, however. Here, we identify PDZD8—the mammalian ortholog of a...

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Detalles Bibliográficos
Autores principales: Shirane, Michiko, Wada, Mariko, Morita, Keiko, Hayashi, Nahoki, Kunimatsu, Reina, Matsumoto, Yuki, Matsuzaki, Fumiko, Nakatsumi, Hirokazu, Ohta, Keisuke, Tamura, Yasushi, Nakayama, Keiichi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486383/
https://www.ncbi.nlm.nih.gov/pubmed/32917905
http://dx.doi.org/10.1038/s41467-020-18413-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486383/
https://www.ncbi.nlm.nih.gov/pubmed/32917905
http://dx.doi.org/10.1038/s41467-020-18413-9

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