Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy

Through in vitro kinase assays and docking studies, we report the synthesis and biological evaluation of a phenothiazine analog J54 with potent TLK1 inhibitory activity for prostate cancer (PCa) therapy. Most PCa deaths result from progressive failure in standard androgen deprivation therapy (ADT),...

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Detalles Bibliográficos
Autores principales: Singh, Vibha, Bhoir, Siddhant, Chikhale, Rupesh V., Hussain, Javeena, Dwyer, Donard, Bryce, Richard A., Kirubakaran, Sivapriya, De Benedetti, Arrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486443/
https://www.ncbi.nlm.nih.gov/pubmed/32905878
http://dx.doi.org/10.1016/j.isci.2020.101474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486443/
https://www.ncbi.nlm.nih.gov/pubmed/32905878
http://dx.doi.org/10.1016/j.isci.2020.101474

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