α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synucl...

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Detalles Bibliográficos
Autores principales: Van Laar, Victor S., Chen, Jianming, Zharikov, Alevtina D., Bai, Qing, Di Maio, Roberto, Dukes, April A., Hastings, Teresa G., Watkins, Simon C., Greenamyre, J. Timothy, St Croix, Claudette M., Burton, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486459/
https://www.ncbi.nlm.nih.gov/pubmed/32905883
http://dx.doi.org/10.1016/j.redox.2020.101695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486459/
https://www.ncbi.nlm.nih.gov/pubmed/32905883
http://dx.doi.org/10.1016/j.redox.2020.101695

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