Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements

Chromosomal translocations fusing the locus of nucleoporin NUP214 each with the proto-oncogenes SET and DEK are recurrent in, largely intractable, acute leukemias. The molecular basis underlying the pathogenesis of SET-NUP214 and DEK-NUP214 are still poorly understood, but both chimeras inhibit prot...

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Detalles Bibliográficos
Autores principales: Mendes, Adélia, Jühlen, Ramona, Martinelli, Valérie, Fahrenkrog, Birthe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486696/
https://www.ncbi.nlm.nih.gov/pubmed/32934780
http://dx.doi.org/10.18632/oncotarget.27711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486696/
https://www.ncbi.nlm.nih.gov/pubmed/32934780
http://dx.doi.org/10.18632/oncotarget.27711

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