Brain-wide structural and functional disruption in mice with oligodendrocyte-specific Nf1 deletion is rescued by inhibition of nitric oxide synthase

Neurofibromin gene (NF1) mutation causes neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss in adult oligodendrocytes causes myelin decompaction and increases oligodendrocyte nitri...

Descripción completa

Detalles Bibliográficos
Autores principales: Asleh, Jad, Shofty, Ben, Cohen, Nadav, Kavushansky, Alexandra, López-Juárez, Alejandro, Constantini, Shlomi, Ratner, Nancy, Kahn, Itamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486714/
https://www.ncbi.nlm.nih.gov/pubmed/32839340
http://dx.doi.org/10.1073/pnas.2008391117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486714/
https://www.ncbi.nlm.nih.gov/pubmed/32839340
http://dx.doi.org/10.1073/pnas.2008391117

Ejemplares similares