Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

Increased neural stem cell (NSC) quiescence is a major determinant of age-related regenerative decline in the adult hippocampus. However, a coextensive model has been proposed in which division-coupled conversion of NSCs into differentiated astrocytes restrict the stem cell pool with age. Here we re...

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Detalles Bibliográficos
Autores principales: White, Charles W., Fan, Xuelai, Maynard, Jason C., Wheatley, Elizabeth G., Bieri, Gregor, Couthouis, Julien, Burlingame, Alma L., Villeda, Saul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486730/
https://www.ncbi.nlm.nih.gov/pubmed/32848054
http://dx.doi.org/10.1073/pnas.2007439117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486730/
https://www.ncbi.nlm.nih.gov/pubmed/32848054
http://dx.doi.org/10.1073/pnas.2007439117

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