Cargando…
Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation
Increased neural stem cell (NSC) quiescence is a major determinant of age-related regenerative decline in the adult hippocampus. However, a coextensive model has been proposed in which division-coupled conversion of NSCs into differentiated astrocytes restrict the stem cell pool with age. Here we re...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486730/ https://www.ncbi.nlm.nih.gov/pubmed/32848054 http://dx.doi.org/10.1073/pnas.2007439117 |