Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription

Among several reversible epigenetic changes occurring during transcriptional activation, only demethylation of histones and cytosine-phosphate-guanines (CpGs) in gene promoters and other regulatory regions by specific demethylase(s) generates reactive oxygen species (ROS), which oxidize DNA and othe...

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Detalles Bibliográficos
Autores principales: Sengupta, Shiladitya, Wang, Haibo, Yang, Chunying, Szczesny, Bartosz, Hegde, Muralidhar L., Mitra, Sankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486736/
https://www.ncbi.nlm.nih.gov/pubmed/32826329
http://dx.doi.org/10.1073/pnas.1919445117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486736/
https://www.ncbi.nlm.nih.gov/pubmed/32826329
http://dx.doi.org/10.1073/pnas.1919445117

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