Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov state models

DNA glycosylase is responsible for repairing DNA damage to maintain the genome stability and integrity. However, how glycosylase can efficiently and accurately recognize DNA lesions across the enormous DNA genome remains elusive. It has been hypothesized that glycosylase translocates along the DNA b...

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Detalles Bibliográficos
Autores principales: Peng, Sijia, Wang, Xiaowei, Zhang, Lu, He, Shanshan, Zhao, Xin Sheng, Huang, Xuhui, Chen, Chunlai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486748/
https://www.ncbi.nlm.nih.gov/pubmed/32820079
http://dx.doi.org/10.1073/pnas.2002971117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486748/
https://www.ncbi.nlm.nih.gov/pubmed/32820079
http://dx.doi.org/10.1073/pnas.2002971117

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