Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

Conformational diversity and self-cross-reactivity of antigens have been correlated with evasion from neutralizing antibody responses. We utilized single cell B cell sequencing, biolayer interferometry and X-ray crystallography to trace mutation selection pathways where the antibody response must re...

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Detalles Bibliográficos
Autores principales: Burnett, Deborah L., Schofield, Peter, Langley, David B., Jackson, Jennifer, Bourne, Katherine, Wilson, Emily, Porebski, Benjamin T., Buckle, Ashley M., Brink, Robert, Goodnow, Christopher C., Christ, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486785/
https://www.ncbi.nlm.nih.gov/pubmed/32855302
http://dx.doi.org/10.1073/pnas.2005102117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486785/
https://www.ncbi.nlm.nih.gov/pubmed/32855302
http://dx.doi.org/10.1073/pnas.2005102117

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