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Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens
Conformational diversity and self-cross-reactivity of antigens have been correlated with evasion from neutralizing antibody responses. We utilized single cell B cell sequencing, biolayer interferometry and X-ray crystallography to trace mutation selection pathways where the antibody response must re...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486785/ https://www.ncbi.nlm.nih.gov/pubmed/32855302 http://dx.doi.org/10.1073/pnas.2005102117 |