An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles

Intratumor heterogeneity (ITH) is a biomarker of tumor progression, metastasis, and immune evasion. Previous studies evaluated ITH mostly based on DNA alterations. Here, we developed a new algorithm (DEPTH) for quantifying ITH based on mRNA alterations in the tumor. DEPTH scores displayed significan...

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Detalles Bibliográficos
Autores principales: Li, Mengyuan, Zhang, Zhilan, Li, Lin, Wang, Xiaosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486929/
https://www.ncbi.nlm.nih.gov/pubmed/32917965
http://dx.doi.org/10.1038/s42003-020-01230-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486929/
https://www.ncbi.nlm.nih.gov/pubmed/32917965
http://dx.doi.org/10.1038/s42003-020-01230-7

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