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Indirect regulation of HMGB1 release by gasdermin D

The protein high-mobility group box 1 (HMGB1) is released into the extracellular space in response to many inflammatory stimuli, where it is a potent signaling molecule. Although research has focused on downstream HMGB1 signaling, the means by which HMGB1 exits the cell is controversial. Here we dem...

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Detalles Bibliográficos
Autores principales: Volchuk, Allen, Ye, Anna, Chi, Leon, Steinberg, Benjamin E., Goldenberg, Neil M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486936/
https://www.ncbi.nlm.nih.gov/pubmed/32917873
http://dx.doi.org/10.1038/s41467-020-18443-3