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Efficient rational modification of non-ribosomal peptides by adenylation domain substitution
Non-ribosomal peptide synthetase (NRPS) enzymes form modular assembly-lines, wherein each module governs the incorporation of a specific monomer into a short peptide product. Modules are comprised of one or more key domains, including adenylation (A) domains, which recognise and activate the monomer...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486941/ https://www.ncbi.nlm.nih.gov/pubmed/32917865 http://dx.doi.org/10.1038/s41467-020-18365-0 |