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Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

Non-ribosomal peptide synthetase (NRPS) enzymes form modular assembly-lines, wherein each module governs the incorporation of a specific monomer into a short peptide product. Modules are comprised of one or more key domains, including adenylation (A) domains, which recognise and activate the monomer...

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Detalles Bibliográficos
Autores principales:	Calcott, Mark J., Owen, Jeremy G., Ackerley, David F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486941/ https://www.ncbi.nlm.nih.gov/pubmed/32917865 http://dx.doi.org/10.1038/s41467-020-18365-0

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