Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain

The small GTPase Ras homolog enriched in the brain (Rheb) can activate mammalian target of rapamycin (mTOR) and regulate the growth and cell cycle progression. We investigated the role of Rheb-mediated mTORC1 signaling in neuropathic pain. A chronic constriction injury (CCI) model was dopted. CCI in...

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Detalles Bibliográficos
Autores principales: Ma, Xiaqing, Du, Wenjie, Wang, Wenying, Luo, Limin, Huang, Min, Wang, Haiyan, Lin, Raozhou, Li, Zhongping, Shi, Haibo, Yuan, Tifei, Jiang, Wei, Worley, Paul F., Xu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487067/
https://www.ncbi.nlm.nih.gov/pubmed/32920594
http://dx.doi.org/10.1038/s41419-020-02966-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487067/
https://www.ncbi.nlm.nih.gov/pubmed/32920594
http://dx.doi.org/10.1038/s41419-020-02966-0

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