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Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain
The small GTPase Ras homolog enriched in the brain (Rheb) can activate mammalian target of rapamycin (mTOR) and regulate the growth and cell cycle progression. We investigated the role of Rheb-mediated mTORC1 signaling in neuropathic pain. A chronic constriction injury (CCI) model was dopted. CCI in...
Autores principales: | Ma, Xiaqing, Du, Wenjie, Wang, Wenying, Luo, Limin, Huang, Min, Wang, Haiyan, Lin, Raozhou, Li, Zhongping, Shi, Haibo, Yuan, Tifei, Jiang, Wei, Worley, Paul F., Xu, Tao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487067/ https://www.ncbi.nlm.nih.gov/pubmed/32920594 http://dx.doi.org/10.1038/s41419-020-02966-0 |
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