Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy

Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase (CHST6) gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS to precipitate in keratocytes and the corneal stroma. We investigated roles for inflammatory responses in MCD pathogene...

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Detalles Bibliográficos
Autores principales: Zheng, Tao, Zhao, Chuchu, Zhao, Baowen, Liu, Hanruo, Wang, Shijian, Wang, Liyuan, Liu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487068/
https://www.ncbi.nlm.nih.gov/pubmed/32983576
http://dx.doi.org/10.1038/s41420-020-00320-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487068/
https://www.ncbi.nlm.nih.gov/pubmed/32983576
http://dx.doi.org/10.1038/s41420-020-00320-z

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