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Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy
Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase (CHST6) gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS to precipitate in keratocytes and the corneal stroma. We investigated roles for inflammatory responses in MCD pathogene...
Autores principales: | Zheng, Tao, Zhao, Chuchu, Zhao, Baowen, Liu, Hanruo, Wang, Shijian, Wang, Liyuan, Liu, Ping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487068/ https://www.ncbi.nlm.nih.gov/pubmed/32983576 http://dx.doi.org/10.1038/s41420-020-00320-z |
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