miRNA-141 Induced Pyroptosis in Intervertebral Disk Degeneration by Targeting ROS Generation and Activating TXNIP/NLRP3 Signaling in Nucleus Pulpous Cells

The role and mechanism of pyroptosis in intervertebral disk (IVD) degeneration are unclear. MicroRNAs (miRNAs) regulate the viability and function of nucleus pulposus cells (NPCs) in IVDs and are related to pyroptosis. We performed microarray analyses of normal and degenerated nucleus pulposus (NP)...

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Detalles Bibliográficos
Autores principales: Xu, Qiaolong, Xing, Hongyuan, Wu, Jiaqi, Chen, Weishan, Zhang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487322/
https://www.ncbi.nlm.nih.gov/pubmed/32984347
http://dx.doi.org/10.3389/fcell.2020.00871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487322/
https://www.ncbi.nlm.nih.gov/pubmed/32984347
http://dx.doi.org/10.3389/fcell.2020.00871

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