Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities

Abnormal metabolism is common in cancer cells and often correlates with mutations in genes encoding for enzymes involved in small-molecule metabolism. Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer. Cancer-associated substitutions in IDH1 and IDH2 impair wi...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Cadoux-Hudson, Tom, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487778/
https://www.ncbi.nlm.nih.gov/pubmed/32777735
http://dx.doi.org/10.1016/j.cbpa.2020.06.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487778/
https://www.ncbi.nlm.nih.gov/pubmed/32777735
http://dx.doi.org/10.1016/j.cbpa.2020.06.012

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