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Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities
Abnormal metabolism is common in cancer cells and often correlates with mutations in genes encoding for enzymes involved in small-molecule metabolism. Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer. Cancer-associated substitutions in IDH1 and IDH2 impair wi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487778/ https://www.ncbi.nlm.nih.gov/pubmed/32777735 http://dx.doi.org/10.1016/j.cbpa.2020.06.012 |