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Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies and states that are also implicated in tissue dysfunction and pathogenesis. Here we leveraged single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models to finely map the trajectories...

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Detalles Bibliográficos
Autores principales: Choi, Jinwook, Park, Jong-Eun, Tsagkogeorga, Georgia, Yanagita, Motoko, Koo, Bon-Kyoung, Han, Namshik, Lee, Joo-Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487779/
https://www.ncbi.nlm.nih.gov/pubmed/32750316
http://dx.doi.org/10.1016/j.stem.2020.06.020