Controlled Cycling and Quiescence Enables Efficient HDR in Engraftment-Enriched Adult Hematopoietic Stem and Progenitor Cells

Genome editing often takes the form of either error-prone sequence disruption by non-homologous end joining (NHEJ) or sequence replacement by homology-directed repair (HDR). Although NHEJ is generally effective, HDR is often difficult in primary cells. Here, we use a combination of immunophenotyping...

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Detalles Bibliográficos
Autores principales: Shin, Jiyung J., Schröder, Markus S., Caiado, Francisco, Wyman, Stacia K., Bray, Nicolas L., Bordi, Matteo, Dewitt, Mark A., Vu, Jonathan T., Kim, Won-Tae, Hockemeyer, Dirk, Manz, Markus G., Corn, Jacob E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487781/
https://www.ncbi.nlm.nih.gov/pubmed/32877675
http://dx.doi.org/10.1016/j.celrep.2020.108093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487781/
https://www.ncbi.nlm.nih.gov/pubmed/32877675
http://dx.doi.org/10.1016/j.celrep.2020.108093

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