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Comparative efficacy of placebos in short-term antidepressant trials for major depression: a secondary meta-analysis of placebo-controlled trials

BACKGROUND: The issue of unblinded outcome-assessors and patients has repeatedly been stressed as a flaw in allegedly double-blind antidepressant trials. Unblinding bias can for example result from a drug‘s marked side effects. If such unblinding bias is present for a given drug, then it might be ex...

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Detalles Bibliográficos
Autores principales: Holper, Lisa, Hengartner, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487933/
https://www.ncbi.nlm.nih.gov/pubmed/32894088
http://dx.doi.org/10.1186/s12888-020-02839-y