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Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer

BACKGROUND: NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown. METHODS: We detected the protein levels of NEK2 in cervical carcinoma tissues and...

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Detalles Bibliográficos
Autores principales: Xu, Tie, Zeng, Yulan, Shi, Linli, Yang, Qin, Chen, Yeshan, Wu, Gang, Li, Guiling, Xu, Shuangbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488040/
https://www.ncbi.nlm.nih.gov/pubmed/32907622
http://dx.doi.org/10.1186/s13046-020-01659-y