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Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells developing from myeloid progenitors, which are enriched in pathological conditions such as cancer, and are known to inhibit the functions of effector T cells. During aging, several changes occur both a...

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Detalles Bibliográficos
Autores principales: Magri, Sara, Masetto, Elena, Solito, Samantha, Francescato, Samuela, Belluzzi, Elisa, Pozzuoli, Assunta, Berizzi, Antonio, Ruggieri, Pietro, Mandruzzato, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488050/
https://www.ncbi.nlm.nih.gov/pubmed/32944054
http://dx.doi.org/10.1186/s12979-020-00199-5