1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression

BACKGROUND: Indoleamine 2, 3-dioxygenase-1 (IDO1) is a promising target for immunotherapy in bladder cancer (BC). IDO1 breaks-down tryptophan to generate kynurenine derivatives, which may activate the aryl hydrocarbon receptor (AHR). AHR is an important target for carcinogens, but its association wi...

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Detalles Bibliográficos
Autores principales: Matheus, Luiz Henrique Gomes, Dalmazzo, Stephanie Vanin, Brito, Rodrigo Barbosa Oliveira, Pereira, Lucas Alves, de Almeida, Robson José, Camacho, Cleber Pinto, Dellê, Humberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488063/
https://www.ncbi.nlm.nih.gov/pubmed/32907554
http://dx.doi.org/10.1186/s12885-020-07371-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488063/
https://www.ncbi.nlm.nih.gov/pubmed/32907554
http://dx.doi.org/10.1186/s12885-020-07371-6

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