Cargando…

Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair

BACKGROUND: Excessive inflammation might activate and injure the blood-brain barrier (BBB), a common feature of many central nervous system (CNS) disorders. We previously developed an in vitro BBB injury model in which the organophosphate paraoxon (PX) affects the BBB endothelium by attenuating junc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Israelov, Hila, Ravid, Orly, Atrakchi, Dana, Rand, Daniel, Elhaik, Shirin, Bresler, Yael, Twitto-Greenberg, Rachel, Omesi, Liora, Liraz-Zaltsman, Sigal, Gosselet, Fabien, Schnaider Beeri, Michal, Cooper, Itzik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488082/ https://www.ncbi.nlm.nih.gov/pubmed/32907600 http://dx.doi.org/10.1186/s12974-020-01927-w

Ejemplares similares

Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway
por: Rand, Daniel, et al.
Publicado: (2021)

Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties
por: Ravid, Orly, et al.
Publicado: (2018)

Definition of the contribution of an Osteopontin-producing CD11c(+) microglial subset to Alzheimer’s disease
por: Qiu, Yiguo, et al.
Publicado: (2023)

High‐fat diet protects the blood–brain barrier in an Alzheimer's disease mouse model
por: Elhaik Goldman, Shirin, et al.
Publicado: (2018)

Transient blood–brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity
por: Sharabi, Shirley, et al.
Publicado: (2019)

BBB opening by low pulsed electric fields, depicted by delayed-contrast MRI, enables efficient delivery of therapeutic doxorubicin doses into mice brains
por: Cooper, Itzik, et al.
Publicado: (2023)

Non-Invasive Low Pulsed Electrical Fields for Inducing BBB Disruption in Mice—Feasibility Demonstration
por: Sharabi, Shirley, et al.
Publicado: (2021)

The application of point source electroporation and chemotherapy for the treatment of glioma: a randomized controlled rat study
por: Sharabi, Shirley, et al.
Publicado: (2020)

Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis
por: Cooper, Itzik, et al.
Publicado: (2021)

High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model
por: Lubitz, Irit, et al.
Publicado: (2016)

How Alpha Linolenic Acid May Sustain Blood–Brain Barrier Integrity and Boost Brain Resilience against Alzheimer’s Disease
por: Leikin-Frenkel, Alicia, et al.
Publicado: (2022)

Albumin–Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells
por: Cooper, Itzik, et al.
Publicado: (2021)

Optimized Glycopeptide Enrichment Method–It Is All About the Sauce
por: Morgenstern, David, et al.
Publicado: (2022)

Caspase-1: an important player and possible target for repair of the blood-brain barrier underlying neurodegeneration
por: Rand, Daniel, et al.
Publicado: (2021)

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
por: Gitik, Miri, et al.
Publicado: (2011)

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury
por: Elberg, Gerard, et al.
Publicado: (2019)

Prevention of dementia presents a potentially critical platform for improvement of long-term public health
por: Beeri, Michal Schnaider
Publicado: (2019)

Cost of Alzheimer's disease
por: Davidson, Michael, et al.
Publicado: (2000)

Publisher Correction: TCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes
por: Ganmore, Ithamar, et al.
Publicado: (2020)

TCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes
por: Ganmore, Ithamar, et al.
Publicado: (2019)

Cognitive Decline and Dementia in the Oldest-Old
por: Kravitz, Efrat, et al.
Publicado: (2012)

Choices of (in)action in obesity: Implications for research on treatment and prevention
por: Arend, Isabel, et al.
Publicado: (2022)

The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review
por: Boccara, Ethel, et al.
Publicado: (2023)

Development and validation of virtual reality-based Rey Auditory Verbal Learning Test
por: Gottlieb, Amihai, et al.
Publicado: (2022)

Serum Cholesterol Concentration on Admission in 415 Dogs Envenomated by Daboia (Vipera) palaestinae as a Marker of Envenomation Severity and Outcome—A Retrospective Study
por: Klainbart, Sigal, et al.
Publicado: (2023)

The effects of cardiovascular risk factors on cognitive compromise
por: Beeri, Michal Schnaider, et al.
Publicado: (2009)

Integrating Health Behavior Theories to Predict COVID-19 Vaccine Acceptance: Differences between Medical Students and Nursing Students
por: Rosental, Hila, et al.
Publicado: (2021)

Specific depression dimensions are associated with a faster rate of cognitive decline in older adults
por: Soleimani, Laili, et al.
Publicado: (2022)

Machine learning for comprehensive prediction of high risk for Alzheimer’s disease based on chromatic pupilloperimetry
por: Lustig-Barzelay, Yael, et al.
Publicado: (2022)

Odorant binding protein 69a connects social interaction to modulation of social responsiveness in Drosophila
por: Bentzur, Assa, et al.
Publicado: (2018)

The Bidirectional Association Between Depression and Severe Hypoglycemic and Hyperglycemic Events in Type 1 Diabetes
por: Gilsanz, Paola, et al.
Publicado: (2018)

Diverse Motor Performances Are Related to Incident Cognitive Impairment in Community-Dwelling Older Adults
por: Beeri, Michal Schnaider, et al.
Publicado: (2021)

Higher Dietary Intake of Advanced Glycation End Products Is Associated with Faster Cognitive Decline in Community-Dwelling Older Adults
por: Schnaider Beeri, Michal, et al.
Publicado: (2022)

Risk of falling among hospitalized patients with high modified Morse scores could be further Stratified
por: Gringauz, Irina, et al.
Publicado: (2017)

Lysyl oxidase inhibition in primary myelofibrosis: A renewed strategy
por: Piasecki, Andrew, et al.
Publicado: (2020)

The multifaceted skyrmion
por: Rho, Mannque, et al.
Publicado: (2017)

The multifaceted skyrmion
por: Brown, Gerald E, et al.
Publicado: (2010)

The multifaceted angina
por: Ferrari, Roberto, et al.
Publicado: (2019)

Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes
por: Livny, Abigail, et al.
Publicado: (2017)

Janus Kinase Signaling Pathway and Its Role in COVID-19 Inflammatory, Vascular, and Thrombotic Manifestations
por: Ravid, Jonathan D., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1pg4mq1l2t7p50rvl89nk59g8u