Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity. Our collection of...

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Detalles Bibliográficos
Autores principales: Mateo, Lidia, Duran-Frigola, Miquel, Gris-Oliver, Albert, Palafox, Marta, Scaltriti, Maurizio, Razavi, Pedram, Chandarlapaty, Sarat, Arribas, Joaquin, Bellet, Meritxell, Serra, Violeta, Aloy, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488324/
https://www.ncbi.nlm.nih.gov/pubmed/32907621
http://dx.doi.org/10.1186/s13073-020-00774-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488324/
https://www.ncbi.nlm.nih.gov/pubmed/32907621
http://dx.doi.org/10.1186/s13073-020-00774-x

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