Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway

BACKGROUND: Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations contribute to cognitive and motor impairment...

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Detalles Bibliográficos
Autores principales: Arenas, Yaiza M., Cabrera-Pastor, Andrea, Juciute, Nora, Mora-Navarro, Eloy, Felipo, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488331/
https://www.ncbi.nlm.nih.gov/pubmed/32917219
http://dx.doi.org/10.1186/s12974-020-01941-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488331/
https://www.ncbi.nlm.nih.gov/pubmed/32917219
http://dx.doi.org/10.1186/s12974-020-01941-y

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